Assistance in the design and construction of the HTS platform
Developing target-relevant biochemical and cell-based assays including optimization, validation and troubleshooting (screening assay robustness, sensitivity, reproducibility)
Evaluation of the novel cell-based screening initiatives for implementation into the group portfolio
Converting assays into HTS format - assay miniaturization to 384-well / 1536-well format
Design and implementation of the key in vitro pharmacology experiments for low-throughput compound profiling (efficacy, selectivity, mechanism of action)
Performing HT screens and hit identification
Statistical analysis, reporting and critical data evaluation for providing a scientific contribution to internal drug discovery projects
Ensuring all tasks and responsibilities are performed according to industry-leading scientific and ethical standards and accurately documented in the lab electronic notebook system
Wymagania
MSc in pharmacology, molecular biology, biotechnology or similar discipline with minimum 2 years of experience in a biotech/pharma setting or Ph.D. in relevant biological sciences
Good knowledge of in vitro pharmacology concepts with a strong focus on at least one of the following areas: intracellular signaling, cancer metabolism, immunology, CNS
Experience in working with cell lines and cell-based assays in microplate format
Prior experience with mid-to-high throughput screening, liquid handling devices and lab automation will be a plus
Analytical and problem-solving skills with proven troubleshooting experience
Well-developed multi-tasking, flexibility and team working skills
scientific presentation and interpersonal communication skills
Fluency in English
Oferujemy
Working in world-class extensive research facilities and modern laboratories.
Daily cooperation and know-how exchange with scientific experts.
Additional benefits: a prepaid lunch card, private medical care, subsidized sports card, and office fruit provision.
Internal Development initiatives including soft & leadership skills training programs.
Recognition Program.
Employee Referral Program.
English & Polish language courses.
Support & incentive bonus for completing Ph.D.
Support in legalization process and relocation package.
