Senior Scientist – Translational Biology (Patient-Derived Models) (m/f/d)

108_613

Obowiązki

• Own the platform execution: Plan, prioritize, and deliver translational workstreams in line with program/grant objectives, timelines, and risk/quality controls. 
• Collaborate with junior scientists during the execution of the grant.
• Primary tissue & model establishment: Coordinate workflows related to the research use of patient-derived tissues; evaluate and process tissue samples, and establish primary cell culture models in both 2D and 3D (spheroid) systems, including optimization of culture conditions for cell growth and differentiation.
• Assay design & validation: Develop and validate potency/phenotypic assays (IC50/EC50, viability/apoptosis, clonogenicity, imaging/HCS), define acceptance criteria (e.g., Z′, S/B, CV), and drive continuous improvement and troubleshooting. 
• QC & authentication: Implement rigorous mycoplasma/sterility testing, STR identity, passage limits, banking strategies, growth tracking, and robust documentation (ELN/LIMS) in line with grant and CRO standards.
• Data integrity & decision-making: Lead data review and interpretation; integrate AI/ML-derived insights with wet-lab findings; prepare decision memos and stage-gate recommendations. 
• Cross-functional coordination: Partner with pathology, HTS/HCS, in vitro pharmacology, in vivo pharmacology, computational biology/AI, and project management to ensure seamless hand-offs and on-time delivery. 
• Reporting & communication: Produce high-quality reports and presentations; ensure compliance with grant requirements; contribute to publication planning and future funding extensions. 
• Mentor junior scientists; instill best practices in experimental design, statistics, and documentation. 

Wymagania

• PhD in molecular/cell biology, oncology, biotechnology or related field and 2+ years postdoc/industry experience preferred; or MSc with strong, relevant track record. 
• Proven hands-on expertise in primary human tumor models (preferably CRC/PDAC): intake logistics, tissue dissociation, 2D/3D culture establishment, media/ECM selection (e.g., BME/Matrigel; Wnt/R-spondin/Noggin-based systems), scaling and stabilization. 
• Demonstrated assay development/validation proficiency: IC50/EC50 analysis, design of controls, plate/randomization strategies, and acceptance metrics (Z′, S/B, CV). 
• Strong QC/authentication practice: mycoplasma/sterility, STR, passage policy/banking; disciplined ELN/LIMS use. 
• Fluent in data analysis and statistics (e.g., 4PL/5PL fitting in GraphPad Prism; outlier/replicate handling); capable of converting data into clear narratives. 
• Experience coordinating cross-disciplinary projects and mentoring scientists; excellent planning, communication, and management skills. 
• Nice to have: HCS/advanced imaging analytics; immune/tumor co-cultures; flow cytometry panels; collaboration with AI/ML teams. 

Oferujemy

• A key scientific role in a funded, high-impact translational oncology program.
• Opportunity to shape a next-generation patient-derived platform integrating primary models, advanced phenotyping and AI/ML. 
• Work in a modern research environment with state-of-the-art equipment and a multidisciplinary team. 
• Professional growth within one of Europe’s fastest-growing biotechnology R&D organizations. 
• Additional benefits: a prepaid lunch card, private medical care, subsidized sports card, and office fruit provision. 
• Internal Development initiatives including soft & leadership skills training programs. 
• Recognition Program. 
• Employee Referral Program. 
• Support & incentive bonus for completing Ph.D. 
• Various sports and engagement initiatives. 

Źródło: Selvita/Praca