Execute routine biochemical and cell-based screening in 384- and 1536-well formats
Prepare reagents, plates, controls and other assay components required for HTS campaigns.
Convert assays into HTS format, including miniaturization to 384-well and 1536-well format.
Perform plate QC checks, monitor assay performance, and ensure compliance with HTS quality criteria (Z’, %CV, S/B, drift).
Contribute to assay design and implementation of the key in vitro pharmacology experiments for low-throughput compound profiling (efficacy, selectivity, mechanism of action).
Perform HT screens and hit identification.
Perform statistical analysis, reporting, and critical data evaluation to support internal drug discovery projects.
Maintain high standards of documentation in the electronic lab notebook.
Ensure all tasks and responsibilities are performed according to industry-leading scientific and ethical standards and accurately documented in the lab electronic notebook (ELN) system.
Good knowledge of flow cytometry will be an advantage.
Wymagania
MSc in pharmacology, molecular biology, biotechnology or related discipline with minimum of 2 years’ experience in a biotech/pharma setting or Ph.D. in relevant biological sciences.
Good knowledge of in vitro pharmacology concepts, with a strong focus on at least one of the following areas: intracellular signaling, cancer metabolism, immunology, or CNS.
Experience working with cell lines and cell-based assays in microplate format.
Basic understanding of assay performance metrics and data analysis.
Strong problem-solving skills, attention to detail, and the ability to follow established protocols.
Ability to work efficiently in a team-oriented, dynamic environment.
Strong scientific presentation and interpersonal communication skills.
Good communication skills and fluency in English.
Oferujemy
Opportunity to work within an established, fully automated HTS platform.
Hands-on experience with state-of-the-art assay technologies and screening equipment.
Professional development in an expanding drug discovery organization.
Supportive and collaborative team environment.
Additional benefits: a prepaid lunch card, private medical care, subsidized sports card, and office fruit provision.
Internal Development initiatives, including soft & leadership skills training programs.
