The John Paul II Catholic University of Lublin

Offer Description

The competition is open to individuals who meet the requirements set out in Art. 113, 116 section 2 of the Act of July 20, 2018, Law on Higher Education and Science and meet the following qualification criteria:

• A PhD degree in biology, biotechnology, or a related field.
• The PhD degree must have been awarded no earlier than seven years before January 1 of the year of employment in the project.
• The PhD degree must have been obtained from an institution other than the John Paul II Catholic University of Lublin (KUL), or the candidate must have completed at least a 10-month continuous and documented postdoctoral fellowship at an institution other than KUL and in a country different from the one where the PhD was awarded.
• Documented research experience, particularly in publishing scientific results in peer-reviewed journals and publishers included in official lists used for the evaluation of research quality — with a minimum of two publications in journals scoring at least 100 points in the field of biology.
• Proficiency in English at a minimum level of B2, confirmed by an appropriate certificate or official statement.
• During the period of receiving this remuneration, the candidate must not receive any other salary funded from the direct costs of research projects financed by the National Science Centre (NCN).
• During the same period, the candidate must not be employed under an employment contract by another employer, including one based outside the territory of Poland.

The aim of the project is to discover the cellular and molecular basis of the antifungal activity of metallacarboranes. At the first stage of the research, the influence of metallacarboranes on the morphology and nanomechanical properties of fungal cells will be performed. Next, homeostasis (e.g. membrane permeability) and virulence factors (e.g. biofilm formation) of C. albicans cells treated with metallacarboranes will be assessed. Flow cytometry analysis is planned to study metallacarborane-mediated C. albicans cell death and the influence of the compounds on the cell cycle. The proposed study on the transcriptome of C. albicans using Next-Generation Sequencing followed by bioinformatic data analysis and Real-Time qPCR is aimed at assessment of changes in gene expression caused by metallacarboranes. Finally, the effect of the compounds on the proteome of the fungus will be studied, and an attempt will be undertaken to reveal the C. albicans protein interacting partner of the compounds using affinity chromatography.

Where to apply

E-mail wm@kul.pl

Requirements

• Research Field: Biological sciences
• Education Level: PhD or equivalent

Specific Requirements

• Research interests focused on the antimicrobial activity of chemical compounds,
• Experience in working with microorganisms,
• Experience in working in a biological laboratory,
• Experience in protein analysis using electrophoretic techniques,
• Theoretical (and possibly practical) knowledge of the MALDI-TOF method in proteomic analysis,
• Ability to analyze data using dedicated software, prepare reports, and interpret research results,
• Proven participation in scientific conferences,
• Participation in research grant projects or in applying for external research funding.

Languages

• ENGLISH Level: Good

Additional Information

Eligibility criteria

Candidates entering the competition are asked to submit the following documents:

• 1. CV
• 3. A copy of a masters degree in chemistry, pharmacy or a related field
• 4. Information on the scientific, didactic, and organizational achievements of the candidate
• 5. Information on plans for scientific and research work, indicating the expected results
• 6. Statement confirming that KUL will be the primary place of work if the competition is won
• 7. Statement that the requirements specified in Art. 113 of the Law on Higher Education and Science are met
• 8. References, opinion on predispositions for scientific work

Please include the following phrase in your cover letter:

I consent to the processing of my personal data for the purpose and to the extent necessary for recruitment in accordance with the Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and regarding free movement of such data and repealing Directive 95/46/EC (General Data Protection Regulation), published OJ Device UE L No. 119, p. 1. Consent is voluntary. Failure to consent means that you will not be able to participate in the recruitment process. Consent may be withdrawn at any time, but without affecting the lawfulness of the processing of personal data carried out on the basis of consent before its withdrawal.

Selection process

The first stage of the competition procedure is the formal verification of submitted documents. Applications that pass the formal verification are subject to substantive evaluation, during which a recruitment interview may be conducted (directly or via electronic communication channels), after prior agreement on the date with the Candidate.

Resolution of the competition does not result in the establishment of an employment relationship.

The final decision on employment is made by the Rector.

The University reserves the right to close the competition without a decision.

Additional comments

The John Paul II Catholic University of Lublin does not provide housing.